The Btb and Cnc Homology 1 (bach1) Target Genes Are Involved in the Oxidative Stress Response and in the Control of the Cell Cycle*
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چکیده
THE BTB AND CNC HOMOLOGY 1 (BACH1) TARGET GENES ARE INVOLVED IN THE OXIDATIVE STRESS RESPONSE AND IN THE CONTROL OF THE CELL CYCLE* Hans-Jörg Warnatz, Dominic Schmidt, Thomas Manke, Ilaria Piccini, Marc Sultan, Tatiana Borodina, Daniela Balzereit, Wasco Wruck, Alexey Soldatov, Martin Vingron, Hans Lehrach, and Marie-Laure Yaspo From Department of Vertebrate Genomics and Computational Molecular Biology, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany Running head: Cellular pathways affected by the BACH1 regulatory network Address correspondence to: Marie-Laure Yaspo, PhD, Dept. of Vertebrate Genomics, Ihnestrasse 63-73, 14195 Berlin, Germany. Tel.: +49-30-8413-1356; Fax: +49-30-8413-1128; E-mail: [email protected]
منابع مشابه
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
The regulation of gene expression in response to environmental signals and metabolic imbalances is a key step in maintaining cellular homeostasis. BTB and CNC homology 1 (BACH1) is a heme-binding transcription factor repressing the transcription from a subset of MAF recognition elements at low intracellular heme levels. Upon heme binding, BACH1 is released from the MAF recognition elements, res...
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